Lili Reinhart Discusses Premenstrual Dysphoric Disorder After Stopping Antidepressants
LOS ANGELES — Actress Lili Reinhart has spoken publicly about her experience with premenstrual dysphoric disorder (PMDD) following her decision to stop taking antidepressants and birth control, officials said. Reinhart, known for her roles in television and film, shared her story during an appearance on the podcast “Reclaiming with Monica Lewinsky,” where she discussed the impact of medication on her mental health and the challenges of living with PMDD.
Reinhart explained that after discontinuing her antidepressants, she became aware of symptoms that had previously been subdued by medication. “When I went off my antidepressants, I realized I had a plethora of other things that were being subdued by medication,” she said. She described experiencing severe mood changes, including suicidal thoughts, in the week before her menstrual period.
Premenstrual dysphoric disorder is characterized by a range of mood, behavioral, and physical symptoms that occur cyclically before menstruation and typically subside afterward, according to the National Institutes of Health. The condition affects an estimated 5% to 8% of women of reproductive age with moderate to severe symptoms such as depression, anxiety, fatigue, and physical pain. The exact cause of PMDD remains unknown.
Reinhart noted that she was unaware of the severity of her symptoms until she stopped taking medication. “I thought everyone feels like shit before their period, but two years ago, I remember texting my mom and saying, ‘I genuinely feel suicidal,’ and then it was a week later, I would get my period and go, ‘Oh,'” she said. She now tracks her symptoms carefully to anticipate and manage difficult days.
In addition to discussing PMDD, Reinhart emphasized the importance of advocating for one’s health, inspired in part by her grandmother’s experience with delayed cancer diagnosis. “The most important thing I have taken away from this experience is the absolute need to advocate for your own health,” she said.
Reinhart’s openness has resonated with many people facing similar challenges, drawing praise for raising awareness about a condition that is often misunderstood. Mental health resources, including the National Suicide Prevention Lifeline and other support organizations, are available for those in need.
Her full interview is available on the “Reclaiming with Monica Lewinsky” podcast, where she further explores her journey with mental health and self-care.

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